Sinapine thiocyanate( —— )

Catalog No. M19063 CAS No. 7431-77-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Sinapine thiocyanate
Note

Research use only, not for human use.
Brief Description

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800).
Description

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer’s disease (AD).
In Vitro

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.
In Vivo

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

Others
Research Area

Others-Field
Indication

——

1. Zhang QS, et al. Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4345-8.

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